Deep space. Beyond our solar system. Monte (Robert Pattinson) and his infant daughter Willow live together aboard a spacecraft, in complete isolation. Radio silence.

Monte is a solitary man, whose strict self-discipline is a protection against desire – his own and that of others - Monte fathered this girl against his will. His sperm was used by Dr. Dibs (Juliette Binoche) to inseminate Boyse (Mia Goth), the young woman who gave birth to her. They were members of a crew composed of prisoners: space convicts, death row inmates. Guinea pigs sent on a mission to the black hole closest to Earth.

High Life marks Juliette Binoche's second film with Claire Denis as director following the internationally acclaimed Un beau soleil intérieur. The film premièred to critical acclaim at the 2018 Toronto International Film Festival.